model field assignment

I would like to remove multiplicative items in several fields of the
model.
I do not know how to save changes:

for Lists in [a.SynGREn, a.SynGREnn]:
.......
...... make changes in field by editing Lists, i.e. cropping part of
text: changed_text=crop(Lists, words)
.......Lists=changed_text
....... a.save()

HOW to save these changes to model back?
# a.save() does save changes for model field a.SynGREn ,
a.SynGREnn

#Suppose threre is a model GRE, with Char fields SynGREn,
SynGREnn

for Lists in [a.SynGREn, a.SynGREnn]:
strc=''
List=Lists.split(',')
for item in List:
if (len(item)!=0):
searchs='\s+'+item+'\s+'
if ( re.search(searchs, strc)==None ):
strc=strc+', '+item+' '
Lists=strc
a.save();
#saves changes only for variable Lists, not for model field a.SynGREn
or a.SynGREnn

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