I have solved the problem with the support from newrelic, the issue was related to the configuration of wsgi. I have 3 VHosts for the application. I switched from wsgi embedded mode to daemon mode. Additionally I have added these two lines for each VHost:
WSGIDaemonProcess www.agileamp.com user=user group=group processes=2 threads=15 display-name=%{GROUP}
WSGIProcessGroup www.agileamp.com
Best regards, Tom
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